The fascinating theory of fetal programming of adult diseases: A review of the fundamentals of the Barker hypothesis
J Public Health Res. 2024 Mar 1;13(1):22799036241226817. doi: 10.1177/22799036241226817. eCollection 2024 Jan.ABSTRACTThe theory of fetal programming of adult diseases was first proposed by David J.P. Barker in the eighties of the previous century, to explain the higher susceptibility of some people toward the development of ischemic heart disease. According to his hypothesis, poor maternal living conditions during gestation represent an important risk factor for the onset of atherosclerotic heart disease later in life. The analysis of the early phases of fetal development is a fundamental tool for the risk stratification ...
Source: Atherosclerosis - March 4, 2024 Category: Cardiology Authors: Gavino Faa Vassilios Fanos Mirko Manchia Peter Van Eyken Jasjit S Suri Luca Saba Source Type: research

Nomogram developed with < em > APOA5 < /em > genetic variant rs662799 and clinical characteristics predicting risk of essential hypertension in a Chinese population
CONCLUSIONS: In our study, the rs662799 variant of the APOA5 gene was significantly associated with susceptibility to EHT. A nomogram for the early prediction of EHT in in the Chinese population was successfully constructed and validated. The nomogram can provide a visual assessment of the risk of EHT for clinical consultation.PMID:38434565 | PMC:PMC10904303 | DOI:10.21037/cdt-23-289 (Source: Atherosclerosis)
Source: Atherosclerosis - March 4, 2024 Category: Cardiology Authors: Dilihumaer Abulaiti Shajidan Abudureyimu Hui Li Yan Cao Ying Gao Source Type: research

Association between the composite dietary antioxidant index and metabolic syndrome: evidence from NHANES 2003-2018
CONCLUSIONS: A non-linear association was found between CDAI and decreased MetS risk, which indicated that selective combined intake of antioxidants could be a promising and effective approach to preventing MetS for the public.PMID:38436185 | DOI:10.26355/eurrev_202402_35481 (Source: Pharmacological Reviews)
Source: Pharmacological Reviews - March 4, 2024 Category: Drugs & Pharmacology Authors: Z-Y Liao M-H Xiao Q She B-Q Xiong Source Type: research

Association between the composite dietary antioxidant index and metabolic syndrome: evidence from NHANES 2003-2018
CONCLUSIONS: A non-linear association was found between CDAI and decreased MetS risk, which indicated that selective combined intake of antioxidants could be a promising and effective approach to preventing MetS for the public.PMID:38436185 | DOI:10.26355/eurrev_202402_35481 (Source: European Review for Medical and Pharmacological Sciences)
Source: European Review for Medical and Pharmacological Sciences - March 4, 2024 Category: Drugs & Pharmacology Authors: Z-Y Liao M-H Xiao Q She B-Q Xiong Source Type: research

Mechanisms of adverse mammary effect induced by olanzapine and therapeutic interventions in rat model
CONCLUSIONS: These results shed light on the previously overlooked effect of olanzapine on mammary development and present experimental evidence to support current clinical management strategies of antipsychotic induced side effects in the breast.PMID:38437955 | DOI:10.1016/j.taap.2024.116876 (Source: Toxicology and Applied Pharmacology)
Source: Toxicology and Applied Pharmacology - March 4, 2024 Category: Toxicology Authors: Yingyue Dong Xiaozhe Sun Hanxiao Li Chunmiao Han Yue Zhang Huiru Ding Lisha Xia Huamin Wang Shaomin Yang Lingzi Xu Guoheng Xu Source Type: research