Exploring a New Pathophysiological Association in Acne Vulgaris and Metabolic Syndrome: The Role of Biogenic Amines and Glutathione Peroxidase
Conclusions: The complex connection between GTPx and catecholamines in MetS suggests a significant role of these factors in the pathogenesis of acne associated with this condition, opening new perspectives in the research and treatment of acne in the context of MetS.PMID:38541239 | PMC:PMC10971819 | DOI:10.3390/medicina60030513 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Alexa Florina Bungau Delia Mirela Tit Manuela Stoicescu Lavinia-Cristina Moleriu Mariana Muresan Ada Radu Mihaela Cristina Brisc Timea Claudia Ghitea Source Type: research
Exploring a New Pathophysiological Association in Acne Vulgaris and Metabolic Syndrome: The Role of Biogenic Amines and Glutathione Peroxidase
Conclusions: The complex connection between GTPx and catecholamines in MetS suggests a significant role of these factors in the pathogenesis of acne associated with this condition, opening new perspectives in the research and treatment of acne in the context of MetS.PMID:38541239 | PMC:PMC10971819 | DOI:10.3390/medicina60030513 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Alexa Florina Bungau Delia Mirela Tit Manuela Stoicescu Lavinia-Cristina Moleriu Mariana Muresan Ada Radu Mihaela Cristina Brisc Timea Claudia Ghitea Source Type: research
Discovery of novel and selective farnesoid X receptor antagonists through structure-based virtual screening, preliminary structure-activity relationship study, and biological evaluation
Eur J Med Chem. 2024 Mar 18;269:116323. doi: 10.1016/j.ejmech.2024.116323. Online ahead of print.ABSTRACTFarnesoid X receptor (FXR) is a bile acids receptor and plays a crucial role in regulating bile acids, lipids, and glucose metabolism. Previous research suggests that inhibiting FXR activation can be beneficial in reducing cholesterol and low-density lipoprotein cholesterol (LDL-C) levels, offering potential treatment options for metabolic syndrome with lipid disorders. Herein, we report p-acetylaminobenzene sulfonate derivatives as a novel scaffold of FXR antagonists by multistage screening. Among these derivatives, co...
Source: European Journal of Medicinal Chemistry - March 28, 2024 Category: Chemistry Authors: Xiaodong Dou Tongyu Huo Yameng Liu Zichen Pang Lingyu Su Xinyi Zhao Xing Peng Zhenming Liu Liangren Zhang Ning Jiao Source Type: research
Exploring a New Pathophysiological Association in Acne Vulgaris and Metabolic Syndrome: The Role of Biogenic Amines and Glutathione Peroxidase
Conclusions: The complex connection between GTPx and catecholamines in MetS suggests a significant role of these factors in the pathogenesis of acne associated with this condition, opening new perspectives in the research and treatment of acne in the context of MetS.PMID:38541239 | PMC:PMC10971819 | DOI:10.3390/medicina60030513 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Alexa Florina Bungau Delia Mirela Tit Manuela Stoicescu Lavinia-Cristina Moleriu Mariana Muresan Ada Radu Mihaela Cristina Brisc Timea Claudia Ghitea Source Type: research
Discovery of novel and selective farnesoid X receptor antagonists through structure-based virtual screening, preliminary structure-activity relationship study, and biological evaluation
Eur J Med Chem. 2024 Mar 18;269:116323. doi: 10.1016/j.ejmech.2024.116323. Online ahead of print.ABSTRACTFarnesoid X receptor (FXR) is a bile acids receptor and plays a crucial role in regulating bile acids, lipids, and glucose metabolism. Previous research suggests that inhibiting FXR activation can be beneficial in reducing cholesterol and low-density lipoprotein cholesterol (LDL-C) levels, offering potential treatment options for metabolic syndrome with lipid disorders. Herein, we report p-acetylaminobenzene sulfonate derivatives as a novel scaffold of FXR antagonists by multistage screening. Among these derivatives, co...
Source: European Journal of Medicinal Chemistry - March 28, 2024 Category: Chemistry Authors: Xiaodong Dou Tongyu Huo Yameng Liu Zichen Pang Lingyu Su Xinyi Zhao Xing Peng Zhenming Liu Liangren Zhang Ning Jiao Source Type: research
Exploring a New Pathophysiological Association in Acne Vulgaris and Metabolic Syndrome: The Role of Biogenic Amines and Glutathione Peroxidase
Conclusions: The complex connection between GTPx and catecholamines in MetS suggests a significant role of these factors in the pathogenesis of acne associated with this condition, opening new perspectives in the research and treatment of acne in the context of MetS.PMID:38541239 | PMC:PMC10971819 | DOI:10.3390/medicina60030513 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Alexa Florina Bungau Delia Mirela Tit Manuela Stoicescu Lavinia-Cristina Moleriu Mariana Muresan Ada Radu Mihaela Cristina Brisc Timea Claudia Ghitea Source Type: research
Exploring a New Pathophysiological Association in Acne Vulgaris and Metabolic Syndrome: The Role of Biogenic Amines and Glutathione Peroxidase
Conclusions: The complex connection between GTPx and catecholamines in MetS suggests a significant role of these factors in the pathogenesis of acne associated with this condition, opening new perspectives in the research and treatment of acne in the context of MetS.PMID:38541239 | PMC:PMC10971819 | DOI:10.3390/medicina60030513 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Alexa Florina Bungau Delia Mirela Tit Manuela Stoicescu Lavinia-Cristina Moleriu Mariana Muresan Ada Radu Mihaela Cristina Brisc Timea Claudia Ghitea Source Type: research
Exploring a New Pathophysiological Association in Acne Vulgaris and Metabolic Syndrome: The Role of Biogenic Amines and Glutathione Peroxidase
Conclusions: The complex connection between GTPx and catecholamines in MetS suggests a significant role of these factors in the pathogenesis of acne associated with this condition, opening new perspectives in the research and treatment of acne in the context of MetS.PMID:38541239 | PMC:PMC10971819 | DOI:10.3390/medicina60030513 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Alexa Florina Bungau Delia Mirela Tit Manuela Stoicescu Lavinia-Cristina Moleriu Mariana Muresan Ada Radu Mihaela Cristina Brisc Timea Claudia Ghitea Source Type: research
Exploring a New Pathophysiological Association in Acne Vulgaris and Metabolic Syndrome: The Role of Biogenic Amines and Glutathione Peroxidase
Conclusions: The complex connection between GTPx and catecholamines in MetS suggests a significant role of these factors in the pathogenesis of acne associated with this condition, opening new perspectives in the research and treatment of acne in the context of MetS.PMID:38541239 | PMC:PMC10971819 | DOI:10.3390/medicina60030513 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Alexa Florina Bungau Delia Mirela Tit Manuela Stoicescu Lavinia-Cristina Moleriu Mariana Muresan Ada Radu Mihaela Cristina Brisc Timea Claudia Ghitea Source Type: research
Navigating the Landscape of Cardiovascular Risk Scores: A Comparative Analysis of Eight Risk Prediction Models in a High-Risk Cohort in Lithuania
Conclusions: The choice of RPM can substantially influence clinical decision-making and patient management. The PCE and AusCVDRisk models exhibited the highest degree of agreement while the SCORE2 model consistently exhibited low agreement with other models.PMID:38542029 | DOI:10.3390/jcm13061806 (Source: Atherosclerosis)
Source: Atherosclerosis - March 28, 2024 Category: Cardiology Authors: Petras Navickas Laura Lukavi čiūtė Sigita Glaveckait ė Arvydas Baranauskas Agn ė Šatrauskienė Jolita Badarien ė Aleksandras Laucevi čius Source Type: research
Navigating the Landscape of Cardiovascular Risk Scores: A Comparative Analysis of Eight Risk Prediction Models in a High-Risk Cohort in Lithuania
Conclusions: The choice of RPM can substantially influence clinical decision-making and patient management. The PCE and AusCVDRisk models exhibited the highest degree of agreement while the SCORE2 model consistently exhibited low agreement with other models.PMID:38542029 | PMC:PMC10971708 | DOI:10.3390/jcm13061806 (Source: Atherosclerosis)
Source: Atherosclerosis - March 28, 2024 Category: Cardiology Authors: Petras Navickas Laura Lukavi čiūtė Sigita Glaveckait ė Arvydas Baranauskas Agn ė Šatrauskienė Jolita Badarien ė Aleksandras Laucevi čius Source Type: research
Exploring a New Pathophysiological Association in Acne Vulgaris and Metabolic Syndrome: The Role of Biogenic Amines and Glutathione Peroxidase
Conclusions: The complex connection between GTPx and catecholamines in MetS suggests a significant role of these factors in the pathogenesis of acne associated with this condition, opening new perspectives in the research and treatment of acne in the context of MetS.PMID:38541239 | PMC:PMC10971819 | DOI:10.3390/medicina60030513 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Alexa Florina Bungau Delia Mirela Tit Manuela Stoicescu Lavinia-Cristina Moleriu Mariana Muresan Ada Radu Mihaela Cristina Brisc Timea Claudia Ghitea Source Type: research
Exploring a New Pathophysiological Association in Acne Vulgaris and Metabolic Syndrome: The Role of Biogenic Amines and Glutathione Peroxidase
Conclusions: The complex connection between GTPx and catecholamines in MetS suggests a significant role of these factors in the pathogenesis of acne associated with this condition, opening new perspectives in the research and treatment of acne in the context of MetS.PMID:38541239 | PMC:PMC10971819 | DOI:10.3390/medicina60030513 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Alexa Florina Bungau Delia Mirela Tit Manuela Stoicescu Lavinia-Cristina Moleriu Mariana Muresan Ada Radu Mihaela Cristina Brisc Timea Claudia Ghitea Source Type: research
Exploring a New Pathophysiological Association in Acne Vulgaris and Metabolic Syndrome: The Role of Biogenic Amines and Glutathione Peroxidase
Conclusions: The complex connection between GTPx and catecholamines in MetS suggests a significant role of these factors in the pathogenesis of acne associated with this condition, opening new perspectives in the research and treatment of acne in the context of MetS.PMID:38541239 | PMC:PMC10971819 | DOI:10.3390/medicina60030513 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Alexa Florina Bungau Delia Mirela Tit Manuela Stoicescu Lavinia-Cristina Moleriu Mariana Muresan Ada Radu Mihaela Cristina Brisc Timea Claudia Ghitea Source Type: research
Exploring a New Pathophysiological Association in Acne Vulgaris and Metabolic Syndrome: The Role of Biogenic Amines and Glutathione Peroxidase
Conclusions: The complex connection between GTPx and catecholamines in MetS suggests a significant role of these factors in the pathogenesis of acne associated with this condition, opening new perspectives in the research and treatment of acne in the context of MetS.PMID:38541239 | PMC:PMC10971819 | DOI:10.3390/medicina60030513 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - March 28, 2024 Category: Universities & Medical Training Authors: Alexa Florina Bungau Delia Mirela Tit Manuela Stoicescu Lavinia-Cristina Moleriu Mariana Muresan Ada Radu Mihaela Cristina Brisc Timea Claudia Ghitea Source Type: research
