Non-alcoholic fatty liver disease: pathogenesis and models
Am J Transl Res. 2024 Feb 15;16(2):387-399. doi: 10.62347/KMSA5983. eCollection 2024.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) is a complex disease characterized by a massive accumulation of lipids in the liver, with a continuous progression of simple steatosis, non-alcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma. Non-alcoholic fatty liver disease is associated with obesity, insulin resistance, and metabolic syndrome; it is a severe public health risk and is currently the most common liver disease of the world. In addition to the fatty infiltration of the liver in non-alcoholic fatty liver...
Source: American Journal of Translational Research - March 11, 2024 Category: Research Authors: Hanxiang Zhong Jiayong Dong Liye Zhu Jiaxi Mao Junfeng Dong Yuanyu Zhao You Zou Meng Guo Guoshan Ding Source Type: research

Effect of Semaglutide and Empagliflozin on Pulmonary Structure and Proteomics in Obese Mice
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - March 11, 2024 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity Source Type: research

An Update on the Role and Potential Molecules in Relation to Ruminococcus gnavus in Inflammatory Bowel Disease, Obesity and Diabetes Mellitus
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - March 11, 2024 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity Source Type: research

Risk Prediction of Diabetes Progression Using Big Data Mining with Multifarious Physical Examination Indicators
(Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy)
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - March 11, 2024 Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity Source Type: research

Association between insulin resistance, metabolic syndrome and its components and lung cancer: a systematic review and meta-analysis
A growing body of evidence points to the association between insulin resistance (IR), metabolic syndrome (MetS) and its components and lung cancer incidence, but remains controversial and unknown. (Source: Diabetology and Metabolic Syndrome)
Source: Diabetology and Metabolic Syndrome - March 11, 2024 Category: Endocrinology Authors: Jingxuan Liu, Rui Wang, Song Tan, Xiaohu Zhao and Aihua Hou Tags: Review Source Type: research

Molecules, Vol. 29, Pages 1239: Saponins from Allium macrostemon Bulbs Attenuate Endothelial Inflammation and Acute Lung Injury via the NF- & kappa;B/VCAM-1 Pathway
In this study, we discovered that saponins from Allium macrostemon bulbs (SAMB) effectively inhibited inflammation in human umbilical vein endothelial cells induced by the exogenous inflammatory mediator lipopolysaccharide or the endogenous inflammatory mediator tumor necrosis factor-α, as evidenced by a significant reduction in the expression of pro-inflammatory factors and vascular cell adhesion molecule-1 (VCAM-1) with decreased monocyte adhesion. By employing the NF-κB inhibitor BAY-117082, we demonstrated that the inhibitory effect of SAMB on VCAM-1 expression may be attributed to the NF-&a...
Source: Molecules - March 11, 2024 Category: Chemistry Authors: Li Liu Liang Qiu Jing Xue Chao Zhong Manman Qin Yifeng Zhang Chuanming Xu Yanfei Xie Jun Yu Tags: Article Source Type: research

Sex differences in the relationship between serum total bilirubin and risk of incident metabolic syndrome in community-dwelling adults: Propensity score analysis using longitudinal cohort data over 16 years
Research on identifiable risks for metabolic syndrome (MetS) is ongoing, and growing evidence suggests that bilirubin is a potent antioxidant and cytoprotective agent against MetS. Ho... (Source: Cardiovascular Diabetology)
Source: Cardiovascular Diabetology - March 11, 2024 Category: Cardiology Authors: Ae Hee Kim, Da-Hye Son, Mid-Eum Moon, Soyoung Jeon, Hye Sun Lee and Yong-Jae Lee Tags: Research Source Type: research

Pathophysiology of Overactive Bladder and Pharmacologic Treatments Including β3-Adrenoceptor Agonists -Basic Research Perspectives
Int Neurourol J. 2024 Feb;28(Suppl 1):12-33. doi: 10.5213/inj.2448002.001. Epub 2024 Feb 29.ABSTRACTOveractive bladder (OAB) is a symptom-based syndrome defined by urinary urgency, frequency, and nocturia with or without urge incontinence. The causative pathology is diverse; including bladder outlet obstruction (BOO), bladder ischemia, aging, metabolic syndrome, psychological stress, affective disorder, urinary microbiome, localized and systemic inflammatory responses, etc. Several hypotheses have been suggested as mechanisms of OAB generation; among them, neurogenic, myogenic, and urothelial mechanisms are well-known hypo...
Source: International Neurourology Journal - March 10, 2024 Category: Urology & Nephrology Authors: Joonbeom Kwon Duk Yoon Kim Kang Jun Cho Mamoru Hashimoto Kanako Matsuoka Tadanobu Kamijo Zhou Wang Sergei Karnup Anne M Robertson Pradeep Tyagi Naoki Yoshimura Source Type: research

Pathophysiology of Overactive Bladder and Pharmacologic Treatments Including β3-Adrenoceptor Agonists -Basic Research Perspectives
Int Neurourol J. 2024 Feb;28(Suppl 1):12-33. doi: 10.5213/inj.2448002.001. Epub 2024 Feb 29.ABSTRACTOveractive bladder (OAB) is a symptom-based syndrome defined by urinary urgency, frequency, and nocturia with or without urge incontinence. The causative pathology is diverse; including bladder outlet obstruction (BOO), bladder ischemia, aging, metabolic syndrome, psychological stress, affective disorder, urinary microbiome, localized and systemic inflammatory responses, etc. Several hypotheses have been suggested as mechanisms of OAB generation; among them, neurogenic, myogenic, and urothelial mechanisms are well-known hypo...
Source: International Neurourology Journal - March 10, 2024 Category: Urology & Nephrology Authors: Joonbeom Kwon Duk Yoon Kim Kang Jun Cho Mamoru Hashimoto Kanako Matsuoka Tadanobu Kamijo Zhou Wang Sergei Karnup Anne M Robertson Pradeep Tyagi Naoki Yoshimura Source Type: research